CLOTRIMAZOLE AND BETAMETHASONE DIPROPIONATE SKIN
Inflammation and/or other disease processes in the skin may increase percutaneous absorption of topical corticosteroids. Topical corticosteroids can be absorbed from normal intact skin. Pharmacokinetics: The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle, the integrity of the epidermal barrier and the use of occlusive dressings (see DOSAGE AND ADMINISTRATION section). No single-step or multiple-step resistance to clotrimazole has developed during successive passages of Trichophyton mentagrophytes.īetamethasone dipropionate, a corticosteroid, has been shown to have topical (dermatologic) and systemic pharmacologic and metabolic effects characteristic of this class of drugs. Resistance to azoles including clotrimazole has been reported in some Candida species. The methylsterols may affect the electron transport system, thereby inhibiting growth of fungi.Īctivity In Vivo: Clotrimazole has been shown to be active against most strains of the following dermatophytes, both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section: Epidermophyton floccosum, Trichophyton mentagrophytes, and Trichophyton rubrum.Īctivity In Vitro: In vitro, clotrimazole has been shown to have activity against many dermatophytes, but the clinical significance of this information is unknown.ĭrug Resistance: Strains of dermatophytes having a natural resistance to clotrimazole have not been reported. This leads to the accumulation of 14-(-methylsterols and reduced concentrations of ergosterol, a sterol essential for a normal fungal cytoplasmic membrane.
Imidazoles inhibit 14-(-demethylation of lanosterol in fungi by binding to one of the cytochrome P-450 enzymes.
Mechanism of Action: Clotrimazole is an imidazole antifungal agent.
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